⁠Highlights of some key findings

At Canon Medical, we are collaborating with researchers worldwide to develop innovative stroke solutions. Explore some of our key findings here.

Ultrasound

What is the role of Superb Micro-vascular Imaging (SMI) in the detection of carotid plaque neovascularization?

Intraplaque neovascularization (IPN) is a key feature of plaque instability but its detection is traditionally difficult with B-mode and Doppler Imaging.
Case example of an asymptomatic patient with more than 70% carotid stenosis (predominantly hypoechoic plaque) in the right internal carotid artery. ​On CEUS, bubbles moving into the plaque core can be observed. Similarly, intraplaque microvascular flow signals moving towards the plaque core can be observed on SMI as well.
  • SMI performed in 31 patients with internal carotid stenosis ≥50% and compared to CEUS and histology

  • Very strong relationship between SMI and CEUS (correlation r=0.911, P<0.001)

  • Plaques with higher IPN grades on SMI also showed significantly more neovessels on histology
Case example of an asymptomatic patient with more than 70% carotid stenosis (predominantly hypoechoic plaque) in the right internal carotid artery. ​On CEUS, bubbles moving into the plaque core can be observed. Similarly, intraplaque microvascular flow signals moving towards the plaque core can be observed on SMI as well.
Conclusion: “These findings demonstrate that SMI can detect neovascularization with accuracy comparable to CEUS, suggesting SMI as a promising noninvasive alternative to CEUS.”

Reference:
Zamani et al. | Carotid Plaque Neovascularization Detected With Superb Microvascular Imaging Ultrasound Without Using Contrast Media | Stroke (2019)
https://pubmed.ncbi.nlm.nih.gov/31510899/

CT x HIT

How does whole brain (16 cm) perfusion vs. traditional brain (4 cm) perfusion support decision making?

With a scanner that acquires less than the entire brain in a rotation, the user has to make sacrifices in either coverage or accuracy. This study compared the impact of performing CT perfusion with whole brain (16 cm) coverage versus traditional (4 cm) coverage in the assessment of cerebral ischemia.
Conclusion: “The increased field of view better defined the true extent of the identified infarct core and ischemic penumbra. It also showed other areas of infarction that were not identified on the 4 cm Z-axis.”

Reference:
Page et al. | Comparison of 4 cm Z-axis and 16 cm Z-axis multidetector CT perfusion | European radiology (2010)
https://pubmed.ncbi.nlm.nih.gov/20013273/

Healthcare IT

What is the performance of Automation Platform (AP) in the detection of large vessel occlusion (LVO)?

303 consecutive patients with acute ischemic stroke symptoms.
Time from pushing case to receiving LVO results is < 70s.
Correctly predicted large vessel occlusion (LVO) in case with right middle cerebral artery (MCA) occlusion. Top row shows coronal and axial views of the correctly labeled LVO, as indicated by the red box*. Bottom row shows the same case with 2D MIP subtraction and 3D MIP subtraction (right) where you can visualize the lack of contrast distal to the occlusion. * Not available in all geographies.
All cases; n=303:
Accuracy 81%
Sensitivity 73%
Specificity 98%

Internal carotid artery (ICA); n=160:
Accuracy 95%
Sensitivity 90%
Specificity 98%
Correctly predicted large vessel occlusion (LVO) in case with right middle cerebral artery (MCA) occlusion. Top row shows coronal and axial views of the correctly labeled LVO, as indicated by the red box*. Bottom row shows the same case with 2D MIP subtraction and 3D MIP subtraction (right) where you can visualize the lack of contrast distal to the occlusion. * Not available in all geographies.
Conclusion: “Canon’s Automation Platform Stroke CT LVO application was able to accurately identify ICA and M1 MCA occlusions in addition to almost perfectly assessing when an LVO was not present.”

Reference:
Rava et al. | Validation of an Artificial Intelligence Driven Large Vessel Occlusion Detection Algorithm for Acute Ischemic Stroke Patients | The Neuroradiology Journal (2021)
https://pubmed.ncbi.nlm.nih.gov/33657922/

⁠Online webinars

Watch our latest online webinars, where leading experts from around the world come to share discoveries and insights from research and clinical practice in stroke care.

Join our panel of experts to learn how AI and the Automation Platform are empowering them to meet that need. The Automation Platform is an AI-based, zero-click solution that uses deep learning technology to streamline your workflow for fast, actionable results every time. From scanner to clinical decision, you’ll be supported by innovative deep learning technologies that process and deliver images foraccurate triage, worklist prioritization and treatment decisions.

The Canon Online Neurology Days consist of daily interactive webinars, led by subject matter experts from across the globe. These days will provide a platform for professional education as we discuss state of art imaging and clinical management using illustrative clinical examples.

We will begin by following an acute stroke patient pathway over 3 days; from early detection, through acute diagnostics and into the angio suite.

Transcranial color-coded Duplex sonography (TCCD) and TCS/TCD (Transcranial B-mode sonography) are not the first diagnostic tools to be chosen for an intracranial vessel analysis in acute stroke or early diagnosis of Parkinson’s disease (PD). However, this non-invasive way of high-resolution imaging is a preferred method to follow vascular pathologies, access cerebral hemodynamics and visualize the substantia nigra. This webinar has a strong focus on live scanning where you will be shown how relatively easy you can start with transcranial Duplex sonography of vessels and brain structures, accompanied by a lecture on the clinical background.

Watch more Canon webinars

White papers and case studies⁠

Find our latest white papers and case studies on stroke solutions using Canon technologies here.

Risk Stratification

Ultrasound
Carotid plaque neovascularization detected with Superb Micro-vascular Imaging (SMI) ultrasound without using contrast media

Download this file

Ultrasound
Clinical neurosonology: State of the art and perspectives

Download this file

Triage & Diagnosis

CT
Deep Learning Reconstruction: Getting to the heart of stroke prevention

Download this file

MRI
Moving Forward with Non- Invasive Perfusion Imaging in Clinical Practice

Read article

MRI
French Radiologists Join Forces to Reduce MRI Scan Time with the Vantage Galan 3T

Read article

MRI
Welcome Pack: a standardized brain MR examination with six sequences in less than 5 minutes

Download this file

HIT | CT | MRI
Boosting Acute Stroke Care Through AI- Supported Technology

Read article

HIT | CT
Leveraging Additional Layers of Intelligence

Read article

HIT | CT
Exploring the Potential of AI for Clinical Practice

Read article

HIT | CT
Powering New Tools for Stroke Assessment

Read article

HIT | CT
Emergency department triage: Artificial Intelligence’s gateway to radiology

Read article

HIT | CT
Bayesian CT Perfusion Imaging in Ischemic Stroke

Read article

HIT | CT
AUTOEmergency – Stroke CT Package Used in Clinical Practice at Gates Vascular Institute (GVI)

Read article

HIT | CT
Advancing Stroke Triage with Artificial Intelligence

Read article

Treatment

Angiography
Alphenix Biplane Hi- Def: A Point Where Cutting- Edge Technologies and Fine Art Meet

Read article

Angiography
Neuroendovascular Treatment Using an Angiography System with the Hi- Def Detector

Read article

Angiography
Refine and Redefine Intervention Using High- Definition (Hi- Def) Technology

Read article

Angiography
Transforming Neuroendovascular Therapy with the Alphenix Hi- Def Detector and Workstation

Read article

Angiography
Benefits Using High- Definition (Hi- Def) Technology in Complex Neurovascular Procedures

Read article

Scientific papers

Find our latest scientific evidence on stroke solutions using Canon technologies here.